The reference site for Topotecan

Topotecan (trade name Hycamtin) is a chemotherapeutic agent that is a topoisomerase inhibitor.

WHAT IS Topotecan?

Topotecan belongs to the general group of chemotherapy drugs known as topoisomerase inhibitors.

It is used to treat advanced cervical and ovarian cancers as well and small cell lung cancer that has continued to grow after first–line therapy.

Topotecan works by stopping the growth of cancer cells by preventing the development of elements necessary for cell division.

 

Brand Name(s): Hycamtin
CAS nº: 123948-87-8
(toh poh TEE kan)

 

Product Info

The sections below will provide you with more specific information and guidelines related to topotecan and its correct use. Please read them carefully.

FDA Information

The FDA approved topotecan on May 29th 1996 for the treatment of metastatic ovarian cancer, and then later in December 1998, for the treatment of small cell lung cancer.

Following this, in June 2006, topotecan in combination with cisplatin was approved for advanced cervical cancer that cannot be treated with radiation therapy or surgery.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Topotecan belongs to the general group of chemotherapy drugs known as topoisomerase inhibitors.

It is used to treat advanced cervical and ovarian cancers as well and small cell lung cancer that has continued to grow after first–line therapy.

Topotecan stops the growth of cancer cells by preventing the development of elements necessary for cell division.

Other uses for this medicine

Topotecan has also been investigated for treatment of acute myeloid leukemia, lymphoma, myeloma, breast cancer, colorectal cancer, myelodysplastic syndromes, and pediatric malignancies.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Topotecan is given as an intravenous injection. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion, and can take up to 30 minutes to complete.

Tell your doctor right away if any of this medicine gets on your skin during the injection. If this does happen, the exposed skin should be rinsed thoroughly with soap and warm water.

Topotecan is usually given once daily for 5 days in a row. This treatment is then repeated every 21 days, usually for at least 4 treatments. It may take several weeks for your body to respond to the medication.

Topotecan can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Therefore, it is important that you not miss any scheduled visits to your doctor.

What special precautions should I follow?

BEFORE TAKING TOPOTECAN:

You should not receive topotecan if you have severe bone marrow depression or if you are pregnant or breast-feeding.

Moreover, tell your doctor if you have kidney disease. You may not be able to receive topotecan, or you may need a dosage adjustment or special tests during treatment.

Some drugs may affect topotecan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without first telling your doctor.

This medication falls into the FDA pregnancy category D. This means that it can cause harm to an unborn baby. Do not receive topotecan without telling your doctor if you are pregnant. It could cause harm to the unborn baby, so please use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Additionally, it is not known whether topotecan passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

Topotecan can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. It is important that you not miss any scheduled visits to your doctor.

Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection.

Do not receive a “live” vaccine while you are being treated with topotecan, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you.

Topotecan can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What should I do if I forget a dose?

Contact your doctor for instructions if you miss an appointment for your topotecan injection.

What side effects can this medication cause?

Get emergency medical help if you have any of these signs of an allergic reaction:

hives
difficulty breathing
swelling of your face, lips, tongue, or throat

Call your doctor at once if you have any of these serious side effects:

fever, chills, body aches, or flu symptoms
pale skin, easy bruising or bleeding
unusual weakness
white patches or sores inside your mouth or on your lips
skin changes or severe irritation where the needle is placed

Other less serious side effects are more likely to occur, such as:

bruising or swelling where the medicine was injected
tired feeling
headache, body pain, joint or muscle pain
mild skin rash
loss of appetite
nausea, vomiting, constipation, or stomach pain
temporary hair loss

Other side effects have also been reported. Discuss with your doctor any side effect that occurs during treatment with topotecan.

What storage conditions are needed for this medicine?

Store unopened vials at room temperature between 68 and 77 degrees F (20 and 25 degrees C), and away from light.

Drug diluted and ready for infusion must be used within 24 hours of mixing and can be stored at room temperature up to 77 degrees F (25 degrees C).

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, then please call the local emergency services immediately on 911.

Symptoms of a topotecan overdose may include bone marrow depression, fever, chills, body aches, flu symptoms, sores or white patches in your mouth, or other signs of infection.

Product Images

PICTURES OF TOPOTECAN PRODUCTS

Below you will find images and specific information on the principal types of topotecan that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: HYCAMTIN®
Strength(s): 4 MG
Imprint: HYCAMTIN
Manufacturer: GLAXOSMITHKLINE

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